abstract：:α-Mangostin (MG) is a bioactive compound isolated from mangosteen. This study was aimed to investigate effects of MG on adjuvant-induced arthritis (AA) in rats and decipher the underlying mechanisms. Clinical severity of AA was evaluated by paw oedema, arthritis score, and hematological parameters. Digital radiography...

journal_title：International immunopharmacology

authors： Zuo J,Yin Q,Wang YW,Li Y,Lu LM,Xiao ZG,Wang GD,Luan JJ

更新日期：2018-03-01 00:00:00

abstract：:The aim of the work was to investigate the effect and possible mechanism of MENK on the growth of rat C6 glioma in vivo or in vitro. Our findings showed that MENK could inhibit the growth of rat C6 glioma, prolong median survival times in tumor-bearing rats, and induce glioma cell apoptosis. Moreover, MENK could incre...

journal_title：International immunopharmacology

authors： Lu WC,Xie H,Tie XX,Wang R,Wu AH,Shan FP

更新日期：2018-03-01 00:00:00

abstract：:Liver fibrosis has been emphasized as a serious threat to human health. There is currently no effective clinical drug treatment. Although mogrosides (MGs) have extensive pharmacological effects with minimal toxicity, their effects on liver function, inflammation, matrix metalloproteinases and hepatic stellate cell (HS...

journal_title：International immunopharmacology

authors： Cao F,Zhang Y,Li W,Shimizu K,Xie H,Zhang C

更新日期：2018-02-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) plays critical roles in inducing and exacerbating allergic diseases. Chemical compounds that induce TSLP production can enhance sensitization to antigens and exacerbate allergic inflammation. Hence, identifying such chemicals will be important to prevent an increase in allergic dise...

journal_title：International immunopharmacology

authors： Weng Y,Mizuno N,Dong J,Segawa R,Yonezawa T,Cha BY,Woo JT,Moriya T,Hiratsuka M,Hirasawa N

更新日期：2018-02-01 00:00:00

abstract：:Outbreaks of hand, foot and mouth disease (HFMD), which is caused by Enterovirus 71 (EV71), have erupted in recent years. Andrographolide sulfonate (Trade name: Xiyanping injection) has been recommended to treat severe HFMD in China because of its conventional antithermic and antitoxic activities, but its actual mecha...

journal_title：International immunopharmacology

authors： Li M,Yang X,Guan C,Wen T,Duan Y,Zhang W,Li X,Wang Y,Zhao Z,Liu S

更新日期：2018-02-01 00:00:00

abstract：:Inflammation plays a pivotal role in the development and progression of diabetic nephropathy (DN). Oridonin (Ori), a component isolated from Rabdosia rubescens, possesses remarkable anti-inflammatory, immunoregulatory and antitumor properties. However, the renoprotective effects of Ori and the underlying molecular mec...

journal_title：International immunopharmacology

authors： Li J,Bao L,Zha D,Zhang L,Gao P,Zhang J,Wu X

更新日期：2018-02-01 00:00:00

abstract：:Red cell-derived microparticles (RMPs) are potential mediators of transfusion-related acute lung injury (TRALI). The aim of this study was to investigate the effects of microparticles present in red cell concentrates (RCC) on polymorphonuclear neutrophil (PMN) respiratory burst and acute lung injury (ALI) in mice. Mic...

journal_title：International immunopharmacology

authors： Xie R,Yang Y,Zhu Y,Gao L,Jiang X,Sun J,Bian M,Yang J

更新日期：2018-02-01 00:00:00

abstract：:Prenylated flavonoids are a unique class of naturally occurring flavonoids that have various pharmacological activities. In the present study, we investigated the anti-inflammatory effect in murine macrophages of a prenylated flavonoid, 10-oxomornigrol F (OMF), which was isolated from the twigs of Morus alba (Moraceae...

journal_title：International immunopharmacology

authors： Tran PL,Tran PT,Tran HNK,Lee S,Kim O,Min BS,Lee JH

更新日期：2018-02-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising trea...

journal_title：International immunopharmacology

authors： Tavakolpour S,Mahmoudi H,Balighi K,Abedini R,Daneshpazhooh M

更新日期：2018-01-01 00:00:00

abstract：:Dihydrofisetin is a flavanonol derived from some edible wild herbs and traditional Chinese medicines. It has been found to possess many biological activities. However, the anti-inflammatory potential of Dihydrofisetin remains uncharacterized. The aim of the present study was to investigate the anti-inflammatory activi...

journal_title：International immunopharmacology

authors： Li KK,Shen SS,Deng X,Shiu HT,Siu WS,Leung PC,Ko CH,Cheng BH

更新日期：2018-01-01 00:00:00

abstract：:AST2017-01 mainly consists of Rumex crispus and -Cordyceps militaris and has been widely consumed as an herbal medicine or functional food in Korea. Here we investigated the influences of AST2017-01 and its active component, chrysophanol on human mast cell (HMC-1 cell) and human keratinocyte (HaCaT cell)-mediated infl...

journal_title：International immunopharmacology

authors： Jeong HJ,Kim HY,Kim HM

更新日期：2018-01-01 00:00:00

abstract：:This study was designed to investigate the pharmacological efficacy of glycyrrhetinic acid liposome (GAL) against female mice with nonbacterial cystitis induced by cyclophosphamide (CPS). Mice in different groups were subjected to tests for lactate dehydrogenase (LD), cytokine contents (IL-6, TNF-α) in serum, and hist...

journal_title：International immunopharmacology

authors： Ge B,Yang D,Wu X,Zhu J,Wei W,Yang B

更新日期：2018-01-01 00:00:00

abstract：:Autophagy is an intracellular catabolic mechanism essential for recycling intracellular unfolding protein and eliminating toxic protein aggregates. Several studies have shown that deficient autophagy is implicated in the development of Alzheimer's disease (AD) progression. To date, rapidly emerging evidence suggests t...

journal_title：International immunopharmacology

authors： Hong Y,Liu Y,Zhang G,Wu H,Hou Y

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy, safety and tolerability of β-d-mannuronic acid (M2000) in the treatment of ankylosing spondylitis (AS). METHODS:The study was a 12-week randomized, double-blind, placebo-controlled, phase I/II clinical trial with 3 treatment arms: placebo, β-d-mannuronic acid and naproxen. Patients ...

journal_title：International immunopharmacology

authors： Fattahi MJ,Jamshidi AR,Mahmoudi M,Vojdanian M,Yekaninejad MS,Jafarnezhad-Ansariha F,Ahmadi H,Rehm BHA,Matsuo H,Cuzzocrea S,Hosseini M,Hashemi SN,Aghazadeh Z,Mirshafiey A

更新日期：2018-01-01 00:00:00

abstract：:In this study, Mtb8.4 and HspX, which are expressed at proliferating and dormant stages of Mycobacterium tuberculosis (M. tuberculosis), respectively, were chosen to construct two fusion proteins, Mtb8.4-HspX (8.4H) and HspX-Mtb8.4 (H8.4), and we investigated whether the antigen dose and protein sequential order could...

journal_title：International immunopharmacology

authors： Liu W,Li J,Niu H,Lin X,Li R,Wang Y,Xin Q,Yu H,Wu Y,Zhu B,Tan J

更新日期：2017-12-01 00:00:00

abstract：:Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete ...

journal_title：International immunopharmacology

authors： Hairul-Islam MI,Saravanan S,Thirugnanasambantham K,Chellappandian M,Simon Durai Raj C,Karikalan K,Gabriel Paulraj M,Ignacimuthu S

更新日期：2017-12-01 00:00:00

abstract：:Pinocembrin, one of the primary flavonoids in propolis, possesses many biological activities, including anti-inflammation, anti-oxidation and immunoregulation. This study aimed to evaluate whether pinocembrin could attenuate ovalbumin (OVA)-induced allergic airway inflammation in mice and to explore the possible mecha...

journal_title：International immunopharmacology

authors： Gu X,Zhang Q,Du Q,Shen H,Zhu Z

更新日期：2017-12-01 00:00:00

abstract：:The microbial community in the mucosal surfaces is involved in the development of human cancers, including gastric cancer and colorectal cancer. The respiratory tract in the lung also hosts a distinctive microbial community, but the correlation between this community and lung cancer is largely unknown. Here, we examin...

journal_title：International immunopharmacology

authors： Ma QY,Huang DY,Zhang HJ,Wang S,Chen XF

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Various studies have researched the serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis (AS), but the results were inconclusive. The purpose of this study was to systematically evaluate the correlations between serum levels of these adipokines and AS. METHODS:Electronic ...

journal_title：International immunopharmacology

authors： Yang J,Zhang X,Ma Y,Wu M,Hu X,Han R,Yuan Y,Wang M,Chen M,Jiang S,Tong J,Xu S,Xu J,Shuai Z,Zou Y,Pan F

更新日期：2017-11-01 00:00:00

abstract：:Immunoglobulin therapy is the administration of human polyvalent IgG and represents the most effective treatment to prevent recurrent infections in antibody deficiency patients. Primary antibody deficiency represents the main indication of immunoglobulin replacement therapy and includes a wide range of disorders chara...

journal_title：International immunopharmacology

authors： Pecoraro A,Crescenzi L,Granata F,Genovese A,Spadaro G

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Histone deacetylases (HDACs) play an important role in dysregulation of histone acetylation/deacetylation, which is the main driving force of the progression of pulmonary fibrosis. Here we investigated the changes in histone acetylation/deacetylation, and the contribution of specific class I and class II HDAC...

journal_title：International immunopharmacology

authors： Li M,Zheng Y,Yuan H,Liu Y,Wen X

更新日期：2017-11-01 00:00:00

abstract：:Chronic inflammation is a major contributing factor in the pathogenesis of many diseases. Natural product berberine (BBR) exhibits potent anti-inflammatory effect in vitro and in vivo, while the underlying mechanisms remain elusive. Sirt1, a NAD+-dependent protein deacetylase, was recently found to play an important r...

journal_title：International immunopharmacology

authors： Zhang H,Shan Y,Wu Y,Xu C,Yu X,Zhao J,Yan J,Shang W

更新日期：2017-11-01 00:00:00

abstract：:Anti-citrullinated protein antibodies (ACPAs) are a key serological marker of rheumatoid arthritis (RA). To investigate whether miR-let7a downregulated ACPA-induced macrophage activation and arthritis, miR-let7a levels were assessed in the synovial fluid from patients with RA or osteoarthritis (OA). In addition, expre...

journal_title：International immunopharmacology

authors： Zhu W,Yu J,Qiu S,Liu H,Wang Y,Xu X,Shao L,Zhu L,Jiao Y,Liu F,Zhu X

更新日期：2017-10-01 00:00:00

abstract：:Endothelial cell (EC) activation and dysfunction have been linked to a wide variety of vascular inflammatory diseases. However, the role of microRNAs in EC activation and inflammation remains largely unknown. In this study, we found that miR-130b was significantly decreased in human umbilical vein endothelial cells (H...

journal_title：International immunopharmacology

authors： Wang P,Zhang X,Li F,Yuan K,Li M,Zhang J,Li B,Liang W

更新日期：2017-10-01 00:00:00

abstract：:Macrophages are myeloid immune cells which are strategically positioned throughout the body, where they engulf and degrade debris, dead cells, and foreign substances, and coordinating the inflammatory processes. Macrophages can be divided into two extreme subsets, classical activation (M1), and alternatively activatio...

journal_title：International immunopharmacology

authors： Wang Y,Han CC,Cui D,Li Y,Ma Y,Wei W

更新日期：2017-09-01 00:00:00

abstract：:Neuroinflammation plays an important role in the pathogenesis of Parkinson's disease. Interleukin (IL)-10 is one of the most important and best anti-inflammatory cytokines. The objective of this report is to investigate whether IL-10 has any role in protecting ventral mesencephalic (VM) neurons in in vitro model of ne...

journal_title：International immunopharmacology

authors： Zhu Y,Liu Z,Peng YP,Qiu YH

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND AIM:Rheumatoid arthritis treatment aims to control joint damage and any associated complications such as cardiovascular disease. Most anti-inflammatory drugs have a high tendency to cause gastro-intestinal irritation. The present study is designed to investigate the anti-inflammatory effect of carvedilol...

journal_title：International immunopharmacology

authors： Osman AS,Labib DA,Kamel MM

更新日期：2017-09-01 00:00:00

abstract：:Triggered by the successful administration of the proteasome inhibitor bortezomib in kidney transplant recipients with acute or chronic antibody-mediated rejection, we evaluated the effect of the proteasome inhibitor CEP-18770 and of the selective immunoproteasome inhibitor ONX-0914 on cellular and humoral alloimmunit...

journal_title：International immunopharmacology

authors： Eleftheriadis T,Pissas G,Antoniadi G,Liakopoulos V,Stefanidis I

更新日期：2017-09-01 00:00:00

abstract：:Neuroinflammation mediated by NLRP-1 inflammasome plays an important role in the pathogenesis of neurodegeneration diseases such as Alzheimer's disease (AD). Chronic glucocorticoids (GCs) exposure has deleterious effect on the structure and function of neurons and was found to be correlated with development and progre...

journal_title：International immunopharmacology

authors： Zhang B,Zhang Y,Xu T,Yin Y,Huang R,Wang Y,Zhang J,Huang D,Li W

更新日期：2017-08-01 00:00:00

abstract：:Ulcerative colitis (UC), an idiopathic inflammatory bowel disease, not only affects millions of patients worldwide, but also increases the risk of colon cancer. Geniposide is an iridoid glycoside and has many biological activities such as anti-inflammatory and antioxidant. However, its protective efficacy and mechanis...

journal_title：International immunopharmacology

authors： Zhang Z,Li Y,Shen P,Li S,Lu X,Liu J,Cao Y,Liu B,Fu Y,Zhang N

更新日期：2017-08-01 00:00:00

abstract：:Autoimmune regulator (Aire) plays an indispensable role in maintaining central immune tolerance by promoting the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), which lead to the deletion of autoreactive T cells or the induction of Tregs a...

journal_title：International immunopharmacology

authors： Li D,Zhao B,Luo Y,Limbara S,Zhao B,Zou X,Yang W,Li Y

更新日期：2017-08-01 00:00:00

abstract：:Thymoquinone is an antioxidant phytochemical that has been shown to inhibit neuroinflammation. However, little is known about the potential roles of intracellular antioxidant signalling pathways in its anti-inflammatory activity. The objective of this study was to elucidate the roles played by activation of the Nrf2/A...

journal_title：International immunopharmacology

authors： Velagapudi R,Kumar A,Bhatia HS,El-Bakoush A,Lepiarz I,Fiebich BL,Olajide OA

更新日期：2017-07-01 00:00:00

abstract：:Aseptic periprosthetic osteolysis is a complication induced by wear particles after hip joint replacement, which shortens the service life of prostheses. Although many methods have been applied to prevent this complication, the results were not always successful. In the present study, we explored the prophylactic effe...

journal_title：International immunopharmacology

authors： Zhao S,Yan L,Li X,Zhang Z,Sun Y,Wang J

更新日期：2017-06-01 00:00:00

abstract：:This study aimed to investigate the effect and underlying mechanism of long non-coding RNA plasmacytoma variant translocation 1 (PVT1) in lipopolysaccharide (LPS)-induced inflammation injury in HK-2 cells. We established LPS-induced septic acute kidney injury (AKI) model in HK-2 cells. LPS-induced HK-2 cells were tran...

journal_title：International immunopharmacology

authors： Huang W,Lan X,Li X,Wang D,Sun Y,Wang Q,Gao H,Yu K

更新日期：2017-06-01 00:00:00

abstract：AIMS:The present study is to investigate the effect of cordycepin on the expression of heme oxygenase-1 (HO-1) in lipopolysaccharide (LPS)-activated microphages, as well as its mechanism of action. METHODS:Mouse RAW264.7 cells were treated with different concentrations of cordycepin for 0-16h. Western blotting was use...

journal_title：International immunopharmacology

authors： Qing R,Huang Z,Tang Y,Xiang Q,Yang F

更新日期：2017-06-01 00:00:00

abstract：:Metformin is a widely used anti-diabetic drug and increasing evidence suggests that metformin have profound cardioprotective effects under both diabetic and non-diabetic situations. The protective benefits of metformin have been proved in diabetic patients with cardiovascular complications and in experimental animals ...

journal_title：International immunopharmacology

authors： Liu G,Wu K,Zhang L,Dai J,Huang W,Lin L,Ge P,Luo F,Lei H

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND AIMS:In the past decade of clinical studies, the combination of chemotherapy with cytokine induced killer (CIK) cell transfusion has confirmed a promised efficacy in several types of cancer. CIK cells are a mixture of T lymphocytes, generated from peripheral blood mononuclear cells induced by multiple cy...

journal_title：International immunopharmacology

authors： Huang J,Kan Q,Lan,Zhao X,Zhang Z,Yang S,Li H,Wang L,Xu L,Cheng Z,Zhang Y

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Th17/Treg imbalance and the levels of related cytokines are essential in the pathogenesis of autoimmune and infectious diseases. The aim of the current study was to assess the Treg/Th17 balance and the levels of related cytokines associated with various degrees of liver injury in patients with chronic hepati...

journal_title：International immunopharmacology

authors： Liu B,Gao W,Zhang L,Wang J,Chen M,Peng M,Ren H,Hu P

更新日期：2017-05-01 00:00:00

abstract：:The current study focused on the pharmacodynamic activity components of Gentianopsis paludosa against ulcerative colitis (UC) fibrosis including symptoms of intestinal diarrhea and inflammatory. Trinitro-benzene-sulfonic acid induced UC model rats were gavaged with gradient polarity extracts respectively from ethanol-...

journal_title：International immunopharmacology

authors： Lu NH,Zhao HQ,Jing M,Liu X,Ren CZ,Liu XF,Liu JJ,Zhang YX

更新日期：2017-05-01 00:00:00

abstract：:Paraquat is one of the most extensively used herbicides and has high toxicity for humans and animals. However, there is no effective treatment for paraquat poisoning. The aim of the present study was to evaluate the effects of chloroquine on paraquat-induced lung injury in mice. Mice received a single intraperitoneal ...

journal_title：International immunopharmacology

authors： Shen H,Wu N,Wang Y,Zhao H,Zhang L,Li T,Zhao M

更新日期：2017-05-01 00:00:00